The Speyside family firm has bought Tuthilltown Spirits, maker of Hudson whiskey.
The 36-acre site on the banks of the Hudson River includes a visitor centre and gourmet restaurant.
Founded in 2006, it is thought to be the first distiller in the state since the end of prohibition in the USA.
Grant’s bought the Hudson Whiskey brand in 2010, while the founders of the distillery continued to market gin, vodka and other spirits.
The acquisition of the distillery is the Scottish firm’s first move into America’s booming craft distilling sector. It makes rye, corn and bourbon whiskeys, as well as single malt.
In addition to its blended whiskies branded with the Grant’s name, it has Glenfiddich and Balvenie single malts, Drambuie, Hendrick’s Gin brand, Sailer Jerry Spiced Rum and Three Barrels and Raynal brandy. It owns Tullamore whiskey in Ireland, and Milagro tequila distillers in Mexico.
Simon Hunt, chief executive of William Grant & Sons, said: «The entire team at Tuthilltown bring an incredible passion to what they do and possess an entrepreneurial spirit that we will whole-heartedly encourage».